October 1, 1988Canadian Journal of Physiology and Pharmacology

Nitric oxide-induced vasodilation of organic nitrate-tolerant rabbit aorta

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Why the study?

Does nitric oxide induce vasodilation in organic nitrate-tolerant rabbit aorta?

Population

Isolated rabbit aortic rings (RARs) contracted submaximally with phenylephrine

Comparison

Nitric oxide, glyceryl trinitrate, and… vs Buffer only treatment

Design

Preclinical

Authors

CSChristopher J. SlackQueen's University BMBrian E. McLaughlinState University of New York KNKanji NakatsuQueen's University

Discussion

Member takes

Implication

Supports impaired NO formation in nitrate tolerance; hypothesis-generating in animal model and should not yet change clinical practice.

Structured PICO

Does nitric oxide induce vasodilation in organic nitrate-tolerant rabbit aorta?

Population

Isolated rabbit aortic rings (RARs) contracted submaximally with phenylephrine

Intervention

Nitric oxide (NO) (0.3 microM), glyceryl trinitrate (GTN) (0.03 microM), and isosorbide dinitrate (ISDN) (0.12 microM) after a 1-h treatment with 500 microM GTN or 500 microM ISDN to induce tolerance

Comparator

Buffer only treatment (non-tolerant rabbit aortic rings)

Outcome

Time of onset of relaxation and percent relaxation of tissuesurrogate

The study provides preclinical evidence that organic nitrate tolerance involves decreased formation of nitric oxide, as direct NO administration still induces vasodilation in nitrate-tolerant tissues.

Cite This Study

Slack et al. (1988) studied this question.

synapsesocial.com/papers/6a974795209f792fa32700df https://doi.org/10.1139/y88-220

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Nitric oxide-induced vasodilation of organic nitrate-tolerant rabbit aorta

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nitric oxide-induced vasodilation of organic nitrate-tolerant rabbit aorta

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider