Key result
Isosorbide dinitrate spray administered before exercise significantly improved exercise tolerance compared to placebo (p<0.014) in patients with stable exercise-induced angina.
Why the study?
Does isosorbide dinitrate spray improve exercise tolerance in patients with stable exercise-induced angina?
RCT (n=10)
Double-blind
Crossover
Does isosorbide dinitrate spray improve exercise tolerance in patients with stable exercise-induced angina?
Isosorbide dinitrate spray administered 2 minutes prior to exercise significantly improves exercise tolerance and delays electrocardiographic signs of ischemia in patients with stable angina.
Supports pre-exercise isosorbide dinitrate spray in stable angina; confirms short-acting nitrate benefit on exercise tolerance in RCTs.
Ten patients with stable exercise-induced angina took part in this study. Isosorbide dinitrate and placebo sprays were administered in a double-blind, randomized crossover study. The dose of isosorbide dinitrate given was two squirts (= 2.5 mg) 2 min before testing. When taken before exercise it significantly improved (p less than 0.014) exercise tolerance. Significant (p less than 0.0005) ischaemic changes in the electrocardiogram also occurred. These effects occurred later than with placebo. Exercise time was prolonged with the active drug. The results of this study show that isosorbide dinitrate spray improves the exercise tolerance of patients with ischaemic heart disease.
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Äärynen et al. (1986) conducted an RCT in Stable exercise-induced angina (n=10). Isosorbide dinitrate spray vs. Placebo spray was evaluated on Exercise tolerance (p=<0.014). Isosorbide dinitrate spray administered before exercise significantly improved exercise tolerance compared to placebo (p<0.014) in patients with stable exercise-induced angina.
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