Why the study?
Does sublingual isosorbide dinitrate reduce anginal episodes in male patients with classical exertional angina pectoris?
Does sublingual isosorbide dinitrate reduce anginal episodes in male patients with classical exertional angina pectoris?
Sublingual isosorbide dinitrate is no more effective than placebo in treating classical exertional angina pectoris and is associated with a high rate of headaches.
Answers are grounded in this paper and cite their sources.
Sublingual isosorbide dinitrate should not be used routinely for exertional angina; leaves open nitrate efficacy in larger modern trials.
A double-blind crossover study comparing the effects of 5 mg of isosorbide dinitrate given sublingually four times daily for 4 weeks to those of a placebo also administered sublingually four times daily for 4 weeks was performed on 20 male patients with classical exertional angina pectoris due to coronary artery disease. Isosorbide dinitrate, compared to placebo, significantly reduced the number of anginal episodes requiring nitroglycerin in only one of 17 patients (6%), did not significantly improve exercise tolerance in any of 17 patients, and did not improve the resting or exercise electrocardiograms in any of 17 patients. Isosorbide dinitrate produced headaches in 12 of 19 patients (63%), and two of these patients (11%) were unable to tolerate the drug. Isosorbide dinitrate administered sublingually is no more effective than placebo in treating angina pectoris.
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Aronow et al. (1970) studied this question.
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