April 17, 1969New England Journal of Medicine
Propranolol Combined with Isosorbide Dinitrate versus Placebo in Angina Pectoris
Why the study?
Does the combination of sublingual isosorbide dinitrate and oral propranolol improve anginal attacks and exercise performance in patients with angina pectoris?
Population
23 patients with angina pectoris
Comparison
Sublingual isosorbide dinitrate 5 mg combined… vs Appropriate placebos
Design
Other
Follow-up
6 weeks
Authors
Discussion
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Member takes
Implication
Raises caution on propranolol-isosorbide dinitrate for angina; leaves open need for rigorous randomized trials.
Structured PICO
Does the combination of sublingual isosorbide dinitrate and oral propranolol improve anginal attacks and exercise performance in patients with angina pectoris?
P
Population
23 patients with angina pectoris
I
Intervention
Sublingual isosorbide dinitrate 5 mg combined with oral propranolol 40 mg, given four times daily for six weeks
C
Comparator
Appropriate placebos
O
Outcome
Number of anginal attacks and exercise performancepatient reported
The combination of propranolol and isosorbide dinitrate was less effective than placebo in reducing anginal attacks and improving exercise performance, and was poorly tolerated by a subset of patients.
Cite This Study
Aronow et al. (1969) studied this question.