Why the study?
Do verapamil, propranolol, or isosorbide dinitrate reduce daily angina attacks and improve exercise tolerance in patients with angina pectoris compared to placebo?
Population
Patients with angina pectoris (angina of effort)
Comparison
Verapamil, propranolol, and isosorbide dinitrate vs Placebo
Design
RCT, Double-blind
Authors
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Both verapamil and propranolol merit first-line consideration for stable angina; confirms comparable efficacy of calcium-channel blockade and beta-blockade.
Do verapamil, propranolol, or isosorbide dinitrate reduce daily angina attacks and improve exercise tolerance in patients with angina pectoris compared to placebo?
Verapamil and propranolol are effective therapies for reducing angina attacks and improving exercise tolerance, whereas isosorbide dinitrate was ineffective and poorly tolerated due to severe headaches.
Livesley et al. (1973) studied this question.
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