Why the study?
Do verapamil, propranolol, or isosorbide dinitrate reduce daily angina attacks and improve exercise tolerance in patients with angina pectoris compared to placebo?
Do verapamil, propranolol, or isosorbide dinitrate reduce daily angina attacks and improve exercise tolerance in patients with angina pectoris compared to placebo?
Verapamil and propranolol are effective therapies for reducing angina attacks and improving exercise tolerance, whereas isosorbide dinitrate was ineffective and poorly tolerated due to severe headaches.
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Both verapamil and propranolol merit first-line consideration for stable angina; confirms comparable efficacy of calcium-channel blockade and beta-blockade.
Livesley et al. (1973) studied this question.
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