Why the study?
Does propranolol, isosorbide dinitrate, or their combination reduce anginal symptoms and improve exercise capacity in patients with angina pectoris?
Does propranolol, isosorbide dinitrate, or their combination reduce anginal symptoms and improve exercise capacity in patients with angina pectoris?
Propranolol effectively reduces the symptoms of angina pectoris but does not significantly improve exercise performance or prevent ischemic ECG changes, whereas isosorbide dinitrate was ineffective.
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Propranolol reduces anginal frequency; supports beta-blocker use for symptom control and challenges nitrate add-on value in stable angina.
Goldbarg et al. (1969) studied this question.
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