Why the study?
Does the combination of nifedipine and propranolol improve antianginal effects compared to either drug alone or placebo in patients with severe exertional angina pectoris?
Population
16 patients with severe exertional angina pectoris
Comparison
Nifedipine, propranolol, and a combination of… vs Placebo
Design
RCT, double-blind
Authors
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Supports combination therapy in severe exertional angina; confirms additive anti-ischemic benefit over monotherapy.
Does the combination of nifedipine and propranolol improve antianginal effects compared to either drug alone or placebo in patients with severe exertional angina pectoris?
The combination of propranolol and nifedipine provides superior objective and subjective antianginal efficacy compared to either monotherapy or placebo in patients with severe exertional angina.
Lynch et al. (1980) studied this question.
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