What question did this study set out to answer?

To assess how propranolol, isosorbide dinitrate, and their combination affect treadmill exercise performance, subjective symptoms, and adrenergic activity in patients with angina pectoris.

February 1, 1969CirculationOpen Access

Effects of Propranolol and Isosorbide Dinitrate on Exercise Performance and Adrenergic Activity in Patients with Angina Pectoris

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Why the study?

Does oral administration of propranolol, isosorbide dinitrate, or their combination improve exercise performance and clinical symptoms in patients with angina pectoris?

Population

12 patients with angina pectoris

Comparison

Oral administration of propranolol, isosorbide… vs Crossover design comparing propranolol, ISD, and…

Design

Other, single blind

Authors

DBDennis BattockUniversity of Colorado Boulder CCCharles A. ChidseyNational Institutes of Health

Discussion

Member takes

Implication

May support propranolol-ISD combination for angina symptoms; leaves open confirmation in larger randomized trials.

Key Points

To assess how propranolol, isosorbide dinitrate, and their combination affect treadmill exercise performance, subjective symptoms, and adrenergic activity in patients with angina pectoris.
Conducted a single-blind crossover study in 12 patients with angina pectoris.
Administered oral regimens of propranolol alone, isosorbide dinitrate (ISD) alone, and combination therapy.
Evaluated treadmill exercise performance, pressure-rate index, exercise-induced S-T segment depression, and plasma/urinary catecholamines.
Combined clinical improvement occurred in 9 of 12 patients on propranolol, 7 of 10 on ISD, and 10 of 10 on combination therapy; differences in objective treadmill metrics were not statistically significant across regimens, though subjective improvement was markedly higher on combination therapy.
Pressure-rate index decreased by approximately 30% at rest and during exercise on propranolol and combination therapy, whereas no change occurred on ISD alone.
Propranolol alone and in combination with ISD significantly reduced exercise-induced S-T segment depression at grade 3+ pain, while elevated baseline adrenergic activity remained unaltered across all treatments.

Structured PICO

Does oral administration of propranolol, isosorbide dinitrate, or their combination improve exercise performance and clinical symptoms in patients with angina pectoris?

Population

12 patients with angina pectoris

Intervention

Oral administration of propranolol, isosorbide dinitrate (ISD), and a combination of propranolol and ISD

Comparator

Crossover design comparing propranolol, ISD, and their combination

Outcome

Objective changes in exercise performance on the treadmill and subjective, clinical improvementsurrogate

Propranolol, isosorbide dinitrate, and their combination improve exercise performance in angina patients, with the combination providing the greatest subjective clinical improvement.

Cite This Study

Battock et al. (1969) studied this question.

synapsesocial.com/papers/6a8a7959238a34ecf4722d36 https://doi.org/10.1161/01.cir.39.2.157

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Effects of Propranolol and Isosorbide Dinitrate on Exercise Performance and Adrenergic Activity in Patients with Angina Pectoris

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of Propranolol and Isosorbide Dinitrate on Exercise Performance and Adrenergic Activity in Patients with Angina Pectoris

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider