Why the study?
Does the combination of isosorbide dinitrate and pindolol improve exercise tolerance and ECG changes in patients with stable angina pectoris compared to either drug alone or placebo?
Does the combination of isosorbide dinitrate and pindolol improve exercise tolerance and ECG changes in patients with stable angina pectoris compared to either drug alone or placebo?
The combination of isosorbide dinitrate and pindolol provides superior improvement in exercise tolerance compared to either agent alone in patients with stable angina.
Supports combining ISDN and pindolol for superior exercise tolerance in stable angina; extends monotherapy evidence to dual therapy in RCTs.
The effect of placebo, isosorbide dinitrate (ISDN) (5 mg orally), pindolol (1.0 mg i.v.) and the combination of ISDN and pindolol was tested in 12 patients with stable, exercise-induced angina pectoris and normal resting ECG. A graded submaximal exercise test was performed on a bicycle ergometer 30 min after medication. All patients had ST depression during and shortly after exercise. ISDN and pindolol increased exercise tolerance to a similar degree but through different mechanisms. Pindolol decreased heart rate and markedly reduced ST depression in the ECG, while ISDN had no effect on ECG changes. The combination of ISDN and pindolol was superior to either drug alone in increasing exercise tolerance in angina pectoris.
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Liv Storstein (1981) studied this question.
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