Why the study?
Does isosorbide dinitrate or verapamil improve exercise-induced ST-segment depression in male patients with exertion-related angina pectoris?
Does isosorbide dinitrate or verapamil improve exercise-induced ST-segment depression in male patients with exertion-related angina pectoris?
Both isosorbide dinitrate and verapamil provide significant anti-ischemic effects in patients with stable angina, though ISDN efficacy slightly declines over two weeks while verapamil remains unchanged.
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Verapamil provides sustained anti-ischemic benefit without tolerance in stable angina; confirms short-term efficacy of both agents but highlights ISDN limitations.
Schneider et al. (1988) studied this question.
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