What question did this study set out to answer?

This research aims to evaluate the efficacy of combining nifedipine and propranolol in managing chronic stable angina pectoris.

August 1, 1981British Journal of Clinical PharmacologyOpen Access

The combination of nifedipine and propranolol in the management of patients with angina pectoris.

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Why the study?

Does the combination of nifedipine and propranolol improve exercise capacity and reduce anginal attacks in patients with chronic stable angina pectoris?

Population

25 patients with chronic stable angina pectoris at beta-adrenoceptor blockade, some of whom had poor left…

Comparison

Combination of nifedipine and propranolol vs Baseline beta-adrenoceptor blockade in a…

Design

Double-blind

Authors

ATAC TweddelGlasgow Royal Infirmary JBJ M BeattieKing's College London RMR.Daniel MurrayCleveland Clinic

Discussion

Member takes

Implication

Supports combined nifedipine-propranolol use in stable angina; extends evidence for greater synergy at reduced propranolol doses.

Key Points

This research aims to evaluate the efficacy of combining nifedipine and propranolol in managing chronic stable angina pectoris.
Conducted a double-blind crossover study with 25 patients
Utilized a standardized exercise protocol on a bicycle ergometer to measure efficacy
Evaluated patient assessments of anginal attack rates
Combination therapy increased exercise time to angina and improved physical work capacity (measured by VO2 max)
Notable reduction in anginal attack rate was observed
Synergistic effects heightened after reducing propranolol dosage to 50%

Structured PICO

Does the combination of nifedipine and propranolol improve exercise capacity and reduce anginal attacks in patients with chronic stable angina pectoris?

Population

25 patients with chronic stable angina pectoris at beta-adrenoceptor blockade, some of whom had poor left ventricular function

Intervention

Combination of nifedipine and propranolol

Comparator

Baseline beta-adrenoceptor blockade (implied propranolol alone) in a cross-over design

Outcome

Exercise time to angina and physical work capacity (calculated maximal oxygen uptake [VO2 max]) assessed by a standardized exercise protocol using a bicycle ergometersurrogate

The combination of nifedipine and propranolol improves exercise capacity and reduces angina attacks in patients with chronic stable angina, with synergistic benefits particularly evident at reduced beta-blocker doses.

Cite This Study

Tweddel et al. (1981) studied this question.

synapsesocial.com/papers/6a712bb1febe604dd709e25f https://doi.org/10.1111/j.1365-2125.1981.tb01205.x

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The combination of nifedipine and propranolol in the management of patients with angina pectoris.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The combination of nifedipine and propranolol in the management of patients with angina pectoris.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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