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September 1, 1982Journal of International Medical Research

Chronic Stable Angina: Comparison of Verapamil and Propranolol

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Why the study?

Does verapamil improve angina symptoms and exercise capacity compared to propranolol in patients with stable angina pectoris?

Population

19 patients with stable angina pectoris

Comparison

Verapamil 120 mg t.d.s. for 1 month vs Propranolol 160 mg b.d. for 1 month

Design

RCT, randomized, double-blind

Follow-up

1 month per treatment arm

Authors

ESE SouthallRoyal United HospitalNNN R NuttRoyal United HospitalRTR D ThomasSwansea University

Discussion

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Implication

Verapamil may be preferred over propranolol for stable angina to improve exercise capacity; extends RCT comparisons of symptom control versus functional outcomes.

Structured PICO

Does verapamil improve angina symptoms and exercise capacity compared to propranolol in patients with stable angina pectoris?

P
Population
19 patients with stable angina pectoris
I
Intervention
Verapamil 120 mg t.d.s. (three times daily) for 1 month
C
Comparator
Propranolol 160 mg b.d. (twice daily) for 1 month (crossover design)
O
Outcome
Number of attacks of angina (assessed via patient diaries)patient reported

Verapamil is as effective as propranolol in reducing angina attacks but provides superior improvement in exercise capacity for patients with stable angina.

Cite This Study

Southall et al. (1982) studied this question.

synapsesocial.com/papers/6a7472c70081fe7b05dbd41ehttps://doi.org/10.1177/030006058201000509
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical Evaluation of Verapamil in Angina Pectoris1968 · 153 citations
  2. 2Effect of nifedipine on exercise tolerance in angina pectoris.1980 · 13 citations
  3. 3Role of calcium antagonists in cardiovascular therapy.1981 · 56 citations
  4. 4Ambulatory ST segment monitoring. Problems, pitfalls, solutions, and clinical application.1980 · 114 citations
  5. 5Pathogenetic mechanisms of angina pectoris: expanding views.1980 · 138 citations