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April 10, 1982BMJOpen Access

Additive antianginal effect of verapamil in patients receiving propranolol

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Why the study?

Does a single oral dose of verapamil improve exercise tolerance in men with stable angina pectoris receiving propranolol?

Population

10 men with stable angina pectoris not fully relieved by optimal doses of propranolol (mean 218 mg daily)

Comparison

Single oral dose of 120 mg verapamil added to… vs Placebo added to continued propranolol treatment

Design

RCT, double blind

Follow-up

8 hours

Authors

MBMayer BassanCedars-Sinai Medical CenterDWDaniel Weiler‐RavellCarmel Medical CenterOSO ShalevUniversity of Verona

Discussion

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Implication

Single-dose verapamil improves exercise tolerance on propranolol in stable angina; extends evidence for calcium-blocker add-on in incomplete responders.

Key Points

  • This research aims to determine the additive antianginal effect of verapamil in patients who are already on propranolol.
  • Ten men with stable angina pectoris received either 120 mg verapamil or placebo in a double-blind manner.
  • Exercise tolerance was assessed using a bicycle ergometer, both before and after drug administration.
  • Mean resting systolic blood pressure was measured alongside exercise tests.
  • Mean exercise tolerance increased by 118 seconds one hour post-verapamil (p < 0.001).
  • A significant difference of 66 seconds was observed at six hours post-treatment (p < 0.01).
  • Verapamil reduced resting systolic blood pressure by 12 mm Hg (p < 0.01) with no adverse effects noted.

Structured PICO

Does a single oral dose of verapamil improve exercise tolerance in men with stable angina pectoris receiving propranolol?

P
Population
10 men with stable angina pectoris not fully relieved by optimal doses of propranolol (mean 218 mg daily)
I
Intervention
Single oral dose of 120 mg verapamil added to continued propranolol treatment
C
Comparator
Placebo added to continued propranolol treatment
O
Outcome
Exercise tolerance (time to precipitated angina on a bicycle ergometer) measured hourly for eight hourssurrogate

A single oral dose of verapamil significantly improves exercise tolerance when added to propranolol in men with stable angina.

Cite This Study

Bassan et al. (1982) studied this question.

synapsesocial.com/papers/6a1c91c34defe5c851c3ecb9https://doi.org/10.1136/bmj.284.6322.1067
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical Evaluation of Verapamil in Angina Pectoris1968 · 153 citations
  2. 2Double-blind Evaluation of Verapamil, Propranolol, and Isosorbide Dinitrate against a Placebo in the Treatment of Angina Pectoris1973 · 188 citations
  3. 3Verapamil in the treatment of paroxysmal supraventricular tachycardia1974 · 195 citations
  4. 4Verapamil and Norverapamil Plasma Concentrations During Long-Term Therapy in Patients with Hypertrophic Obstructive Cardiomyopathy1980 · 54 citations
  5. 5Physiological disposition of verapamil in man1976 · 243 citations