Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 1982CirculationOpen Access

A double-blind randomized trial of propranolol and verapamil in the treatment of effort angina.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does verapamil improve exercise capacity and left ventricular function compared to propranolol and placebo in patients with stable effort angina?

Population

18 patients with stable effort angina

Comparison

Verapamil 80 mg four times daily vs Propranolol 80 mg four times daily and placebo

Design

RCT, randomized, double-blind, placebo-controlled

Authors

NSN N SadickThe University of SydneyATA. T. H. TanNational University of SingaporePFP. FletcherCancer Research UK Clinical Trials Unit

Discussion

Loading...

Member takes

Implication

Verapamil offers a comparable alternative to propranolol in stable angina; reinforces calcium channel blockade as effective therapy.

Structured PICO

Does verapamil improve exercise capacity and left ventricular function compared to propranolol and placebo in patients with stable effort angina?

P
Population
18 patients with stable effort angina
I
Intervention
Verapamil 80 mg four times daily
C
Comparator
Propranolol 80 mg four times daily and placebo
O
Outcome
Anginal threshold, exercise capacity, and left ventricular function measured by gated equilibrium blood pool scanningsurrogate

Verapamil is an effective alternative to propranolol for improving exercise capacity and left ventricular function in patients with stable effort angina.

Cite This Study

Sadick et al. (1982) studied this question.

synapsesocial.com/papers/6a7472c70081fe7b05dbd41fhttps://doi.org/10.1161/01.cir.66.3.574
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical Evaluation of Verapamil in Angina Pectoris1968 · 153 citations
  2. 2Evaluation of Long-Term Use of Propranolol in Angina Pectoris1969 · 73 citations
  3. 3Evaluation of long-term use of propranolol in angina pectoris1969 · 12 citations
  4. 4Cardiovascular Pharmacology of Propranolol in Man1969 · 165 citations
  5. 5Double-blind comparison of verapamil and practolol in the treatment of angina pectoris1977 · 29 citations