Key result
Verapamil significantly reduced anginal frequency from 5.6 to 2.2 attacks per week (P<0.001) and increased treadmill time compared to placebo in patients with stable exertional angina.
Why the study?
Does verapamil reduce anginal frequency and improve exercise tolerance in patients with stable exertional angina pectoris?
Population
26 patients with stable exertional angina pectoris
Comparison
Verapamil 480 mg/day vs Placebo (crossover design)
Design
RCT, Randomized crossover protocol, Double-blind
Authors
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Verapamil is effective for symptom control in stable angina; confirms its role versus placebo in this RCT.
RCT (n=26)
Double-blind
Crossover
Does verapamil reduce anginal frequency and improve exercise tolerance in patients with stable exertional angina pectoris?
Absolute Event Rate: 2.2% vs 5.6%
p-value: p=<0.001
Verapamil 480 mg/day is safe and effective for reducing angina frequency and improving exercise tolerance in patients with stable exertional angina.
Brodsky et al. (1982) conducted an RCT in Stable exertional angina pectoris (n=26). Verapamil vs. Placebo was evaluated on Anginal frequency (attacks per week) (p=<0.001). Verapamil significantly reduced anginal frequency from 5.6 to 2.2 attacks per week (P<0.001) and increased treadmill time compared to placebo in patients with stable exertional angina.
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