Key result
Verapamil therapy significantly increased treadmill exercise duration from 279 to 452 seconds and reduced weekly anginal attacks from 24 to 9 in patients with chronic stable angina.
Why the study?
Does chronic oral verapamil therapy improve exercise performance in patients with chronic angina pectoris?
Does chronic oral verapamil therapy improve exercise performance in patients with chronic angina pectoris?
Absolute Event Rate: 452% vs 279%
p-value: p=<0.001
Chronic oral verapamil therapy significantly improves exercise capacity and reduces angina frequency and nitroglycerin consumption in patients with stable coronary artery disease.
May improve symptoms in stable angina; hypothesis-generating from Level 3 data, requiring RCTs before practice change.
We have studied the effects of chronic oral verapamil therapy on exercise performance in 26 patients with arteriographically proven coronary disease and positive exercise stress tests. Maximal, multistage treadmill exercise tests were performed before and after 2, 4, and 8 weeks therapy with verapamil 120 mg t.i.d. The time to angina and the distance walked increased from 279 to 452 sec and from 255 to 443 meters respectively. The frequency of anginal attacks decreased from 24 to 9 per week after 8 wk treatment while the nitroglycerin consumption decreased from 20 to 8 tablets per week. Functional aerobic impairment improved from 42.7% to 29.3% whilst there was no change in pressure-rate product, cumulative ST segment depression or EEV1/FVC ratios.
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Kuan et al. (1982) studied Chronic Angina Pectoris (n=26). Verapamil vs. Baseline was evaluated on Duration of treadmill exercise (seconds) (p=<0.001). Verapamil therapy significantly increased treadmill exercise duration from 279 to 452 seconds and reduced weekly anginal attacks from 24 to 9 in patients with chronic stable angina.
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