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March 1, 1976Postgraduate Medical JournalOpen Access

Verapamil in ischaemic heart disease—quantitative assessment by serial multistage treadmill exercise

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Why the study?

Does verapamil 120 mg thrice daily improve anginal threshold and ischemic ST segment changes during exercise in patients with ischemic heart disease?

Population

25 patients with ischaemic heart disease (including 13 symptomatic patients)

Comparison

Verapamil 120 mg thrice daily for 8 weeks vs Baseline assessment without any drugs, and…

Design

Cohort

Follow-up

8 weeks

Authors

VBV. BalasubramanianAnna University, ChennaiGNGayatri NarayananHypertension InstitutePKP K KhannaStrong Memorial Hospital

Discussion

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Implication

May support verapamil in angina; hypothesis-generating from small cohort and requires RCT confirmation.

Structured PICO

Does verapamil 120 mg thrice daily improve anginal threshold and ischemic ST segment changes during exercise in patients with ischemic heart disease?

P
Population
25 patients with ischaemic heart disease (including 13 symptomatic patients)
I
Intervention
Verapamil 120 mg thrice daily (360 mg/day) for 8 weeks
C
Comparator
Baseline assessment without any drugs, and assessment after propranolol 40 mg thrice daily for 3 days
O
Outcome
Computerized ST segment changes, anginal threshold, and other objective parameters during serial multistage treadmill exercisesurrogate

Verapamil 360 mg/day is an effective and well-tolerated antianginal agent that improves exercise-induced ischemia and anginal threshold in patients with ischemic heart disease.

Cite This Study

Balasubramanian et al. (1976) studied this question.

synapsesocial.com/papers/6a1c91c34defe5c851c3ecc1https://doi.org/10.1136/pgmj.52.605.143
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Double-blind Evaluation of Verapamil, Propranolol, and Isosorbide Dinitrate against a Placebo in the Treatment of Angina Pectoris1973 · 188 citations
  2. 2Verapamil in angina: a double-blind trial.1968 · 32 citations
  3. 3Comparison of exercise tests and 24-hour ambulatory electrocardiographic monitoring in detection of ST-T changes.1974 · 81 citations