What question did this study set out to answer?

This study aims to evaluate the impact of verapamil on myocardial function in patients with coronary artery disease.

February 1, 1979Circulation

Effects of verapamil on myocardial performance in coronary disease.

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Why the study?

Does intravenous verapamil improve myocardial performance in patients with coronary artery disease without heart failure?

Key Points

This study aims to evaluate the impact of verapamil on myocardial function in patients with coronary artery disease.
20 patients with coronary artery disease received intravenous verapamil (0.1 mg/kg bolus, followed by 0.005 mg/kg/min infusion).
Patients were examined hemodynamically and angiographically before and after drug administration.
Verapamil significantly decreased mean aortic pressure from 94 +/- 17 to 82 +/- 13 mm Hg (p less than 0.0005).
Cardiac index increased from 2.8 +/- 0.6 to 3.1 +/- 0.7 1/min/m2 (p less than 0.0005).
Ejection fraction improved from 55 +/- 16 to 61 +/- 18% (p less than 0.01).

Structured PICO

Does intravenous verapamil improve myocardial performance in patients with coronary artery disease without heart failure?

Population

20 patients with coronary artery disease (CAD) but no heart failure

Intervention

Intravenous verapamil (0.1 mg/kg bolus, followed by 0.005 mg/kg/min infusion)

Comparator

Baseline (pre-treatment)

Outcome

Hemodynamic and angiographic indices of left ventricular performancesurrogate

In patients with CAD without heart failure, intravenous verapamil improves overall cardiac function because its potent vasodilatory properties overcome its intrinsic negative inotropic effect.

Discussion

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Implication

Verapamil may improve LV performance in CAD without HF; leaves open need for RCTs before any practice change.

Cite This Study

Ferlinz et al. (1979) studied this question.

synapsesocial.com/papers/6a23d76f0f6fe640299f0d05 https://doi.org/10.1161/01.cir.59.2.313

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Effects of verapamil on myocardial performance in coronary disease.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Effects of verapamil on myocardial performance in coronary disease.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider