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February 1, 1979HeartOpen Access

Management of unstable angina at rest by verapamil. A double-blind cross-over study in coronary care unit.

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Why the study?

Does oral verapamil reduce the frequency of transient ischaemic attacks in patients with unstable angina at rest attributed to coronary vasospasm?

Population

12 patients admitted to a coronary care unit with frequent daily attacks of angina at rest attributed to…

Comparison

Oral verapamil 480 mg/day administered during… vs Placebo administered alternately during two…

Design

RCT, Randomised cross-over design (4 alternating 48-hour periods), Double-blind

Follow-up

Four 48-hour periods (total 8 days) after a 48-hour run-in

Authors

OPOberdan ParodiCardiac ImagingAMA MaseriCardiac ImagingISIgnazio SimonettiAzienda Ospedaliero-Universitaria Careggi

Discussion

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Implication

Verapamil merits consideration in vasospastic unstable angina; confirms calcium antagonism efficacy in this RCT.

Structured PICO

Does oral verapamil reduce the frequency of transient ischaemic attacks in patients with unstable angina at rest attributed to coronary vasospasm?

P
Population
12 patients admitted to a coronary care unit with frequent daily attacks of angina at rest attributed to coronary vasospasm.
I
Intervention
Oral verapamil 480 mg/day administered during two 48-hour periods in a cross-over design.
C
Comparator
Placebo administered alternately during two 48-hour periods in a cross-over design.
O
Outcome
Number of transient ischaemic attacks with ST segment elevation or depression, with or without pain, documented by continuous electrocardiographic monitoring.surrogate

Oral verapamil significantly reduces the frequency of ischemic attacks in patients with unstable angina at rest caused by coronary vasospasm.

Cite This Study

Parodi et al. (1979) studied this question.

synapsesocial.com/papers/6a1471bf2398cfa26a89927fhttps://doi.org/10.1136/hrt.41.2.167
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Saphenous Vein Coronary Artery Bypass in Patients with "Preinfarction Angina"1973 · 74 citations
  2. 2Prognosis in unstable angina.1976 · 56 citations
  3. 3Left and right heart haemodynamics during spontaneous angina pectoris. Comparison between angina with ST segment depression and angina with ST segment elevation.1975 · 122 citations
  4. 4Clinical Syndrome of Variant Angina with Normal Coronary Arteriogram1976 · 162 citations