March 1, 1994HeartOpen Access

Verapamil treatment after coronary angioplasty in patients at high risk of recurrent stenosis.

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Why the study?

Does high-dose verapamil reduce angiographic restenosis in patients at high risk of recurrent obstruction after successful coronary angioplasty?

Structured PICO

Does high-dose verapamil reduce angiographic restenosis in patients at high risk of recurrent obstruction after successful coronary angioplasty?

Population

196 consecutive patients undergoing primary successful coronary angioplasty with at least one of six predefined risk factors for restenosis (113 with unstable angina or non-Q wave infarction, 83 with stable angina pectoris).

Intervention

Verapamil 240 mg twice daily added to aspirin 330 mg and dipyridamole 75 mg twice daily.

Comparator

Matching placebo added to aspirin 330 mg and dipyridamole 75 mg twice daily.

Outcome

Angiographic restenosis at 6 months after angioplasty or sooner if signs of recurrent ischaemia developed.surrogate

High-dose verapamil showed a trend toward reducing angiographic restenosis after coronary angioplasty, with a significant reduction observed in the subgroup of patients with stable angina.

Discussion

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Implication

High-dose verapamil did not significantly reduce restenosis after angioplasty; leaves open a possible benefit in stable angina.

Cite This Study

Hoberg et al. (1994) studied this question.

synapsesocial.com/papers/6a701e486c240de38cdbae90 https://doi.org/10.1136/hrt.71.3.254

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