Key result
Treatment with verapamil increased the Cmax of propranolol (227 vs 116 ng/ml, P<0.05) in patients with stable angina pectoris, with transient AV dissociation occurring in two patients.
Why the study?
Does combined therapy with verapamil and propranolol alter their pharmacokinetics and pharmacodynamics in patients with stable angina pectoris?
Population
Patients with stable angina pectoris
Comparison
Combined therapy with oral verapamil and… vs Monotherapy with verapamil or propranolol
Design
Other
Authors
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May warrant caution with verapamil-propranolol co-use in angina; leaves open interaction magnitude in larger cohorts.
Observational
Does combined therapy with verapamil and propranolol alter their pharmacokinetics and pharmacodynamics in patients with stable angina pectoris?
Absolute Event Rate: 227% vs 116%
p-value: p=<0.05
Co-administration of verapamil and propranolol increases propranolol plasma concentrations and carries a risk of transient atrioventricular dissociation, requiring close observation.
McCourty et al. (1988) conducted an observational in stable angina pectoris. Verapamil vs. Propranolol monotherapy was evaluated on Cmax of propranolol (p=<0.05). Treatment with verapamil increased the Cmax of propranolol (227 vs 116 ng/ml, P<0.05) in patients with stable angina pectoris, with transient AV dissociation occurring in two patients.
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