Key result
Repeated co-administration of verapamil and propranolol increased the PR interval by 40% (95% CI 26-54%), trending greater than the expected additive effect of 23% (95% CI 8-38%).
Why the study?
Does the co-administration of verapamil and propranolol cause significant pharmacodynamic or pharmacokinetic interactions in healthy males?
Population
6 healthy males
Comparison
Verapamil and propranolol co-administration vs Verapamil alone and propranolol alone
Design
RCT, randomised, balanced, crossover, double-blind
Authors
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May warrant ECG monitoring for AV delay with repeated co-administration; challenges additive-only models of verapamil-propranolol interaction.
RCT (n=6)
Double-blind
randomised, balanced, crossover
Does the co-administration of verapamil and propranolol cause significant pharmacodynamic or pharmacokinetic interactions in healthy males?
Absolute Event Rate: 40% vs 23%
Co-administration of verapamil and propranolol in healthy subjects shows mostly additive hemodynamic effects, though a greater-than-additive effect on AV conduction (PR interval prolongation) may occur after repeated doses.
Murdoch et al. (1991) conducted an RCT in Healthy subjects (n=6). Verapamil and propranolol combination vs. Verapamil alone and propranolol alone was evaluated on Prolongation of PR interval following repeated doses. Repeated co-administration of verapamil and propranolol increased the PR interval by 40% (95% CI 26-54%), trending greater than the expected additive effect of 23% (95% CI 8-38%).
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