Key result
Alkaline stimulation (pH 9.0) induced reversible intracellular calcium increases in a subset of cultured rat trigeminal neurons, dependent on extracellular calcium influx via L-type calcium channels.
Population
Cultured rat trigeminal neurons
Comparison
Alkaline stimulation vs Baseline pH 7.35
Design
Preclinical
Authors
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Alkaline pH sensitivity in rat trigeminal neurons should not yet change practice; leaves open translation to human nociception mechanisms.
Alkaline pH sensitivity in rat trigeminal neurons is mediated by extracellular calcium influx, likely involving L-type voltage-gated calcium channels, providing a mechanism for alkaline-induced nociception.
Bruce P. Bryant (2005) studied this question. Alkaline pH stimulation vs. Baseline pH 7.35 was evaluated on Intracellular calcium increases. Alkaline stimulation (pH 9.0) induced reversible intracellular calcium increases in a subset of cultured rat trigeminal neurons, dependent on extracellular calcium influx via L-type calcium channels.
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