Key result
Familial sick sinus syndrome with an autosomal dominant trait was identified in a three-generation family, requiring permanent pacemaker implantation in the proband and two sons for symptomatic bradycardia.
Case Report (n=6)
No
This report highlights a familial presentation of sick sinus syndrome with an autosomal dominant inheritance pattern, associated with significant morbidity and mortality including sudden death and stroke.
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May warrant familial screening in clustered bradycardia cases; leaves open validation of inheritance patterns and screening utility in larger cohorts.
Kim et al. (2003) conducted a case report in Familial Sick Sinus Syndrome (n=6). Pacemaker implantation was evaluated. Familial sick sinus syndrome with an autosomal dominant trait was identified in a three-generation family, requiring permanent pacemaker implantation in the proband and two sons for symptomatic bradycardia.
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