Key result
Higher doses of conventional neuroleptics significantly worsened several subjective cognitive and perceptual domains in schizophrenic inpatients (r = 0.44-0.54; P<=0.005-0.05).
Why the study?
Does higher dosage of conventional neuroleptic medication worsen subjective cognitive functioning in schizophrenic inpatients?
Observational (n=40)
Does higher dosage of conventional neuroleptic medication worsen subjective cognitive functioning in schizophrenic inpatients?
Higher doses of conventional neuroleptics are associated with worse subjective cognitive and perceptual functioning in patients with schizophrenia.
Higher conventional neuroleptic doses were associated with worse subjective cognition in schizophrenia; leaves open causality and need for prospective trials.
Subjective cognitive and perceptual disturbances as assessed with the Frankfurt Complaint Questionnaire (FCQ) were correlated with chlorpromazine equivalents in 40 schizophrenic inpatients, who were treated with conventional neuroleptics. In line with previous research using 'objective' neuropsychological tests, both correlations and partial correlations (controlling for the effects of psychopathology, extrapyramidal symptoms and length of illness) confirmed that higher neuroleptic doses significantly worsen several cognitive and perceptual domains (r = 0.44 -0.54; P < or = 0.005 -0.05) with the possible exception of mnestic functions (r = 0.21 -0.24, n.s.) and language (r = 0.37 -0.38, P < 0.1). The clinical importance of self-report scales for evaluating both the risks and benefits of neuroleptic treatment is discussed.
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Krausz et al. (2000) conducted an observational in schizophrenia (n=40). Conventional neuroleptic dosage (chlorpromazine equivalents) was evaluated on Subjective cognitive and perceptual disturbances assessed with the Frankfurt Complaint Questionnaire (FCQ) (r = 0.44-0.54, p=<=0.005-0.05). Higher doses of conventional neuroleptics significantly worsened several subjective cognitive and perceptual domains in schizophrenic inpatients (r = 0.44-0.54; P<=0.005-0.05).
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