Why the study?
Does high-dose neuroleptic treatment improve clinical outcomes or increase adverse reactions compared to low-dose treatment in patients with chronic psychosis?
Population
Patients with chronic psychosis (meta-analysis of 22 published randomized control trials)
Comparison
High-dose neuroleptic treatment vs Low-dose neuroleptic treatment
Design
Meta-analysis
Authors
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May warrant capping neuroleptic doses in chronic psychosis to limit harms; reinforces dose-response plateau in meta-analyses.
Does high-dose neuroleptic treatment improve clinical outcomes or increase adverse reactions compared to low-dose treatment in patients with chronic psychosis?
In patients with chronic psychosis, neuroleptic doses above 375 mg chlorpromazine equivalent provide no additional clinical benefit but significantly increase adverse reactions.
Bollini et al. (1994) studied this question.
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