Key result
Aortic intima-media thickness was highest in diabetic obese patients compared to healthy normal controls, non-diabetic obese, and diabetic non-obese patients.
Why the study?
Non-alcoholic fatty pancreatic disease is associated with unexpected extrapancreatic cardiovascular complications, prompting investigation of its association with carotid and aortic intima-media thickness.
Observational (n=88)
Aortic intima-media thickness varies based on diabetes and obesity status, with the highest thickness observed in diabetic obese patients.
Answers are grounded in this paper and cite their sources.
Diabetic obesity was associated with greatest aortic intima-media thickness; hypothesis-generating and should not yet change practice.
Background: Non-alcoholic fatty pancreatic disease (NAFPD) or fatty pancreas emerged as health problem parallel to obesity . NAFPD can lead to diabetes mellitus,chronic pancreatitis and lastly pancreatic cancer.Extrapancreatic complications to cardio-vascular system is reported too more than expected. Aim: To investigate the association between carotid and aortic intima-media thickness and non-alcoholic fatty pancreas disease . Method: eighty-eight patients divided into 4 groups , group (1)diabetics with normal Body Mass Index( BMI) , group (2) diabetics with BMI over 25 kg/m2 , group(3) non-diabetics with normal BMI , group (4) non diabetics with BMI over 25kg/m2 . All routine investigations necessary done including, Complete Blood Count (CBC), fasting blood sugar , HbA1c%, liver profile including (ALT , AST , GGT , ALP , serum bilirubin and serum albumin) , lipid profile including (cholesterol , triglycerides , HDL , and LDL) , serum insulin level . Abdominal Ultrasound for diagnosis,grading of fatty pancreas and measure Cartotid Intima Media Thickness( CIMT) and Aortic Intima Media Thickness (AIMT). Result: AIMT was as follow (0.96-+0.26) for healthy normal ,(1.38-+0.20)for non DM –obese,(1.24-+0.18)DM , non obese and (1.52-+0.37) forDM –obese patients respectively with p value between the groups =
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El-Badawy et al. (2022) conducted an observational in Non-alcoholic fatty pancreatic disease (NAFPD) (n=88). Diabetes and/or obesity vs. Healthy normal (non-diabetic, normal BMI) was evaluated on Aortic Intima Media Thickness (AIMT). Aortic intima-media thickness was highest in diabetic obese patients compared to healthy normal controls, non-diabetic obese, and diabetic non-obese patients.
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