Key result
A 73-year-old man developed cholesterol crystal embolism 5 months after receiving intravenous thrombolysis for cerebral infarction, highlighting a potential risk for late-onset CCE.
Case Report (n=1)
No
Thrombolysis for cerebral infarction may be associated with late-onset cholesterol crystal embolism, particularly in patients with unstable aortic plaques.
May signal delayed CCE risk after thrombolysis in aortic plaque patients; single case leaves association hypothesis-generating.
A 73-year-old man was admitted to our hospital because of bilateral foot pain. He was treated with thrombolysis for cerebral infarction about 5 months ago. Anticoagulants had not been used because of hemorrhagic infarction. The pulses of bilateral pedal arteries were palpable, but cyanosis was present in the bilateral toes. Laboratory data indicated azotemia and eosinophilia. Magnetic resonance imaging revealed multiple plaques of the thoracic and abdominal aorta, one of which was ulcerated. Skin biopsy proved the diagnosis of cholesterol crystal embolism (CCE). Because no invasive vascular procedure was performed, we assumed that CCE in this patient was related to thrombolysis. We should be cautious for late onset of CCE after thrombolysis.
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Oe et al. (2010) conducted a case report in Cholesterol crystal embolism (n=1). Thrombolysis (alteplase) was evaluated on Development of cholesterol crystal embolism. A 73-year-old man developed cholesterol crystal embolism 5 months after receiving intravenous thrombolysis for cerebral infarction, highlighting a potential risk for late-onset CCE.
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