Key result
During anoxic episodes in anesthetized gerbils, increases in reduced mitochondrial respiratory-chain components were observed only when cortical hemoglobin was more than 85% disoxygenated.
Population
Anesthetized gerbils (cerebral cortex)
Comparison
Anoxic episodes (fraction of inspired oxygen <6%) vs Normoxic conditions
Design
Preclinical
Authors
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Mitochondrial reduction occurs only at extreme hypoxia in gerbil cortex; hypothesis-generating for cerebral oxygen thresholds with no direct clinical translation.
In vivo mitochondrial respiratory-chain components in the gerbil cerebral cortex remain oxidized over a wide range of oxygen delivery, becoming reduced only at severe hypoxia (<6% inspired oxygen).
Bashford et al. (1982) studied Anesthetized gerbils. Anoxic episodes / varying inspired oxygen fractions vs. Normoxia was evaluated on Oxygen metabolism (mitochondrial flavoprotein and pyridine nucleotide fluorescence, ferrocytochromes aa3 and c + c1 levels, oxygen saturation of cortical hemoglobin). During anoxic episodes in anesthetized gerbils, increases in reduced mitochondrial respiratory-chain components were observed only when cortical hemoglobin was more than 85% disoxygenated.
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