Key result
Depressive symptoms (CES-D score ≥16) and antidepressant use were associated with an increased risk of incident atrial fibrillation (HR 1.34, 95% CI 1.04-1.74 and HR 1.36, 95% CI 1.04-1.77).
Why the study?
Current literature examining the prospective relationship between depression and other measures of negative affect with AF is limited.
Are depressive symptoms, anger, anxiety, and chronic stress associated with an increased risk of incident atrial fibrillation in middle- and older-aged adults?
Cohort (n=6,644)
Are depressive symptoms, anger, anxiety, and chronic stress associated with an increased risk of incident atrial fibrillation in middle- and older-aged adults?
Hazard Ratio: 1.34 (95% CI 1.04–1.74)
Depressive symptoms, but not anger, anxiety, or chronic stress, are associated with a significantly increased risk of developing incident atrial fibrillation.
No takes yet. Share an insight, caveat, or question.
Depressive symptoms may warrant inclusion in AF risk assessment; leaves open causality and whether treatment alters incidence.
A 2018 study conducted a cohort in Atrial fibrillation (n=6,644). Depressive symptoms (CES-D score ≥16 or antidepressant use) vs. CES-D score <2 or no antidepressant use was evaluated on incident AF (HR 1.34, 95% CI 1.04-1.74). Depressive symptoms (CES-D score ≥16) and antidepressant use were associated with an increased risk of incident atrial fibrillation (HR 1.34, 95% CI 1.04-1.74 and HR 1.36, 95% CI 1.04-1.77).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: