Key result
The Cre8 polymer-free drug-eluting stent demonstrated equivalent efficacy in diabetic and general populations and showed almost complete strut coverage at three months in clinical studies.
The Cre8 polymer-free drug-eluting stent shows promising efficacy and rapid endothelialization, particularly in diabetic patients, potentially allowing for shorter dual antiplatelet therapy.
Supports evaluation of shorter DAPT in diabetics; leaves open need for randomized confirmation versus contemporary stents.
The use of first-generation drug-eluting stents (DES) has been associated with safety concerns such as very late stent thrombosis. Today, with the release of newer DES, there is a need for comparative studies of percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG) to demonstrate their value in patients with high risk of restenosis such as diabetic patients. In a satellite symposium presented at EuroPCR 2014, the Cre8™ DES was discussed. The Cre8 device has a number of unique clinical features, including polymer-free technology, abluminal reservoir technology and bio-inducer surface that ensure effective neointima suppression and rapid endothelialisation. The efficacy of the Cre8 DES has been demonstrated in the International randomised comparison between DES Limus Carbostent and Taxus drug-eluting stents in the treatment of de novo coronary lesions (NEXT) randomised clinical study, with equivalent efficacy in the diabetic and general populations, a unique finding. Ongoing clinical studies such as Investig8 and the Tel Aviv Medical Center (TLVMC) Cre8 study have confirmed the efficacy of the device in patient populations with a high proportion of diabetic patients. The Demonstr8 randomised trial has shown almost complete Cre8 strut coverage at three months with a numerical advantage versus bare metal stent (bare metal stents [BMS] - comparator device) at one month. In addition, use of the Cre8 DES may enable a shorter duration of dual antiplatelet therapy (DAPT) following PCI. The Cre8 DES therefore represents a significant advance in stent technology and may be particularly useful in challenging clinical settings.
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Mountfort et al. (2014) conducted a review in Coronary artery disease. Cre8 polymer-free drug-eluting stent vs. Taxus drug-eluting stents / Bare metal stents was evaluated. The Cre8 polymer-free drug-eluting stent demonstrated equivalent efficacy in diabetic and general populations and showed almost complete strut coverage at three months in clinical studies.
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