Key result
Drug-eluting stents have raised concerns regarding late stent thrombosis, though recent studies provide reassuring but inconsistent data on long-term rates of death and myocardial infarction.
Why the study?
Do drug-eluting stents improve long-term safety compared with bare-metal stents in patients undergoing percutaneous coronary intervention?
Do drug-eluting stents improve long-term safety compared with bare-metal stents in patients undergoing percutaneous coronary intervention?
Despite reducing restenosis, drug-eluting stents carry concerns for late stent thrombosis requiring prolonged dual antiplatelet therapy, though long-term death and MI rates appear comparable to bare-metal stents.
Concerns over late thrombosis with drug-eluting stents warrant cautious use and prolonged dual antiplatelet therapy; leaves open consistent long-term safety data versus bare-metal stents.
Drug-eluting stents substantially reduce restenosis compared with bare-metal stents and represent a significant advance in percutaneous coronary interventions. Accordingly, drug-eluting stents have been rapidly adopted into practice and are currently used in the vast majority of complex percutaneous coronary procedures. However, in the last 2 years, concerns have been raised regarding their long-term safety, especially regarding the risk of late and very-late stent thrombosis. Delayed endothelial coverage after drug-eluting stent implantation is thought to prolong the window of vulnerability to stent thrombosis, which requires a prolonged dual antiplatelet therapy. Recent registry studies and meta-analyses seem to have provided reassuring results regarding the long-term rates of death and myocardial infarction associated with the use of drug-eluting stents compared with bare-metal stents. However, data are not consistent and concerns remain.
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Rossini et al. (2010) conducted a review in Percutaneous coronary intervention. Drug-eluting stents vs. Bare-metal stents was evaluated. Drug-eluting stents have raised concerns regarding late stent thrombosis, though recent studies provide reassuring but inconsistent data on long-term rates of death and myocardial infarction.
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