Key result
Pilsicainide significantly reduced the incidence of vagally-induced atrial fibrillation originating from the left superior pulmonary vein by causing an impulse conduction block at the pulmonary vein-left atrial junction.
Why the study?
Does pilsicainide prevent the induction of atrial fibrillation originating from the pulmonary vein in a canine model?
Population
14 male dogs total: 6 anesthetized male dogs for in vivo experiments, and 8 isolated canine atria from male…
Comparison
Pilsicainide administered intravenously in… vs Baseline conditions in the same subjects during…
Design
Preclinical
Authors
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Offers preclinical evidence in canine vagal AF; leaves open translation to human pulmonary vein triggers.
Does pilsicainide prevent the induction of atrial fibrillation originating from the pulmonary vein in a canine model?
Absolute Event Rate: 16.7% vs 100%
p-value: p=<0.05
Pilsicainide prevents vagally-induced atrial fibrillation originating from the left superior pulmonary vein by inducing an impulse conduction block at the pulmonary vein-left atrial junction.
Hirose et al. (2007) studied Atrial Fibrillation (n=14). Pilsicainide vs. Control (baseline before pilsicainide administration) was evaluated on Incidence of atrial fibrillation induced by rapid pacing from the distal left superior pulmonary vein during vagal stimulation (p=<0.05). Pilsicainide significantly reduced the incidence of vagally-induced atrial fibrillation originating from the left superior pulmonary vein by causing an impulse conduction block at the pulmonary vein-left atrial junction.
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