Key result
Administration of 4-factor prothrombin complex concentrate rapidly reversed coagulopathy and stabilized bleeding in an 83-year-old male with dabigatran-associated severe gastrointestinal hemorrhage.
Why the study?
Does 4-factor prothrombin complex concentrate reverse coagulopathy in a patient with severe gastrointestinal hemorrhage complicated by dabigatran?
Case Report (n=1)
Does 4-factor prothrombin complex concentrate reverse coagulopathy in a patient with severe gastrointestinal hemorrhage complicated by dabigatran?
4-factor prothrombin complex concentrate may be an effective option for the rapid reversal of dabigatran-induced coagulopathy in patients with life-threatening hemorrhage.
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May support PCC consideration in dabigatran hemorrhage; hypothesis-generating and leaves open need for controlled trials.
McGovern et al. (2015) conducted a case report in Severe gastrointestinal hemorrhage and coagulopathy complicated by dabigatran (n=1). 4-factor prothrombin complex concentrate (4 F-PCC) was evaluated on Reversal of coagulopathy and stabilization of bleeding. Administration of 4-factor prothrombin complex concentrate rapidly reversed coagulopathy and stabilized bleeding in an 83-year-old male with dabigatran-associated severe gastrointestinal hemorrhage.
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