Key result
A prolonged PR interval in first-degree heart block rarely produces significant changes in heart function and will usually return to normal with atropine or sympathomimetic agents.
Why the study?
Does atropine or sympathomimetic agents improve PR interval in patients with first-degree atrioventricular block?
Does atropine or sympathomimetic agents improve PR interval in patients with first-degree atrioventricular block?
First-degree AV block rarely causes significant cardiac dysfunction and, while responsive to atropine or sympathomimetics, typically does not require treatment.
Supports observation over intervention for most first-degree AV block; leaves open prospective validation of progression risk today.
First-Degree BlockPROLONGATION of the PR interval beyond 0.20 second may occur in many disorders including acute myocardial infarction, aortic stenosis, severe aortic insufficiency, adrenal insufficiency, rheumatic fever and a number of systemic infectious diseases. An occasional normal person will have first-degree heart block in the absence of any apparent disease. Although an optimal role for atrial contraction may be provided by a normal PR interval, the delayed onset of ventricular contraction in first-degree block rarely produces significant changes in heart function. A prolonged PR interval will usually return to normal with atropine or sympathomimetic agents, but treatment of this . . .
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Modestino G. Criscitiello (1968) conducted a review in Atrioventricular Block. Atropine or sympathomimetic agents was evaluated. A prolonged PR interval in first-degree heart block rarely produces significant changes in heart function and will usually return to normal with atropine or sympathomimetic agents.
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