Key result
Serum pro-BNP demonstrated high diagnostic accuracy for pulmonary thromboembolism with an AUC of 0.972, yielding 85.4% sensitivity and 80.2% specificity at a cut-off of 100 pg/ml.
Why the study?
Pulmonary thromboembolism is a prevalent disorder with a notable annual fatality rate, motivating evaluation of the diagnostic accuracy of serum pro-BNP and troponin I levels.
Does serum pro-BNP and troponin I improve the diagnosis of pulmonary thromboembolism in patients with suspected PTE?
Cross-Sectional (n=267)
No
Does serum pro-BNP and troponin I improve the diagnosis of pulmonary thromboembolism in patients with suspected PTE?
Pro-BNP demonstrates high diagnostic accuracy for pulmonary thromboembolism and can be a useful adjunctive diagnostic marker, whereas troponin I has poor diagnostic utility in this setting.
INTRODUCTION: Pulmonary thromboembolism (PTE) is one of the most prevalent medical disorders, with a notable annual fatality rate. This study aimed to evaluated the accuracy of serum pro-BNP and troponin I levels in PTE diagnosis. METHODS: This cross-sectional study was implemented on 267 patients with suspected PTE (sudden chest pain or sudden dyspnea) in Imam Reza Hospital in Mashhad, Iran. All patients underwent pulmonary computed tomography (CT) angiography (as the gold standard test) and their serum levels of troponin I and pro-BNP were measured. The screening performance characteristics of pro-BNP in detection of PTE cases were measured and reported using receiver operating characteristic (ROC) curve analysis. RESULTS: Two-hundred-sixty-seven patients with a mean age of 67.7 ±11.5 years were evaluated (60.1% male). PTE was confirmed via CT angiography in 121 patients. The area under the ROC curve of troponin I and pro-BNP in detection of PTE was 0.501 ng/mL and 0.972 pg/mL, respectively. The sensitivity and specificity of proBNP at the best cut-off point (100 pg/ml) were 85.4% and 80.2%, respectively. The sensitivity and specificity of troponin I at the best cut-off point (0.005 ng/ml) were 65.5% and 42%, respectively. CONCLUSION: Due to the comparatively good sensitivity and specificity of proBNP in diagnosis of pulmonary thromboembolism, it can be employed as a diagnostic determinant in patients with suspected pulmonary thromboembolism along with other laboratory tests.
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Ebrahimi et al. (2022) conducted a cross-sectional in Suspected pulmonary thromboembolism (n=267). Serum pro-BNP and troponin I vs. Pulmonary CT angiography was evaluated on Diagnostic accuracy (area under the ROC curve, sensitivity, and specificity) for pulmonary thromboembolism (AUC 0.972 for pro-BNP; AUC 0.501 for troponin I). Serum pro-BNP demonstrated high diagnostic accuracy for pulmonary thromboembolism with an AUC of 0.972, yielding 85.4% sensitivity and 80.2% specificity at a cut-off of 100 pg/ml.
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