Prognostic Role of Brain Natriuretic Peptide in Acute Pulmonary Embolism
Why the study?
Does plasma BNP level at admission predict major adverse cardiovascular events in patients with acute pulmonary embolism?
Population
73 consecutive patients with acute pulmonary embolism (PE)
Design
Cohort
Follow-up
hospital course
Authors
Discussion
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Member takes
Implication
May support BNP-guided risk stratification in acute PE; leaves open prospective validation of the optimal threshold.
Structured PICO
Does plasma BNP level at admission predict major adverse cardiovascular events in patients with acute pulmonary embolism?
P
Population
73 consecutive patients with acute pulmonary embolism (PE)
I
Intervention
Plasma brain natriuretic peptide (BNP) measurement at admission
O
Outcome
Major adverse cardiovascular event (composite of death, cardiopulmonary resuscitation, mechanical ventilation, or use of pressors, thrombolysis, catheter fragmentation, or surgical embolectomy)composite
A lower BNP cut-off of <50 pg/mL, rather than the standard heart failure cut-off of 90 pg/mL, is optimal for identifying acute pulmonary embolism patients with a benign clinical course.
Cite This Study
Kucher et al. (2003) studied this question.