What does this research mean for the field?

Low pro-brain natriuretic peptide (proBNP) levels (<500 pg/mL) independently predict a benign clinical outcome and can identify candidates for abbreviated hospital stays in patients with acute pulmonary embolism. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 31, 2003CirculationOpen Access

Low Pro-Brain Natriuretic Peptide Levels Predict Benign Clinical Outcome in Acute Pulmonary Embolism

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Why the study?

Does proBNP level predict adverse clinical outcomes in patients with acute pulmonary embolism?

Population

73 patients with acute pulmonary embolism (PE)

Comparison

Pro-brain natriuretic peptide level measurement… vs ProBNP levels <500 pg/mL versus higher levels

Design

Cohort

Follow-up

in-hospital

Authors

NKNils KucherVascular Medicine GPGert PrintzenMinistère de l’Environnement et du Développement Durable TDTanja DoernhoeferUniversity Hospital of Bern

Discussion

Member takes

Implication

May aid risk stratification in acute PE; leaves open whether thresholds can safely guide early discharge.

Structured PICO

Does proBNP level predict adverse clinical outcomes in patients with acute pulmonary embolism?

Population

73 patients with acute pulmonary embolism (PE)

Intervention

Pro-brain natriuretic peptide (proBNP) level measurement within 4 hours of admission

Comparator

ProBNP levels <500 pg/mL versus higher levels

Outcome

Adverse clinical outcome (composite of in-hospital death or the need for cardiopulmonary resuscitation, mechanical ventilation, pressors, thrombolysis, catheter fragmentation, or surgical embolectomy)composite

Low proBNP levels (<500 pg/mL) reliably predict a benign in-hospital course in acute pulmonary embolism, potentially identifying candidates for early discharge or outpatient management.

Cite This Study

Kucher et al. (2003) studied this question.

synapsesocial.com/papers/6a1ed21638eb9bccee7e7e7b https://doi.org/10.1161/01.cir.0000064898.51892.09

Topics

Pulmonary embolism

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Low Pro-Brain Natriuretic Peptide Levels Predict Benign Clinical Outcome in Acute Pulmonary Embolism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Low Pro-Brain Natriuretic Peptide Levels Predict Benign Clinical Outcome in Acute Pulmonary Embolism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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