Molecular basis of permeation in voltage-gated ion channels.
Key result
This mini-review focuses on the mechanism of permeation in voltage-gated ion channels, specifically the structural domains that form the pore, determine selectivity, and interact with pore-blockers.
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Implication
May guide targeted antiarrhythmic development; extends structural insights on channel permeation but leaves open clinical translation.
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Cite This Study
Tomaselli et al. (1993) reported a review. This mini-review focuses on the mechanism of permeation in voltage-gated ion channels, specifically the structural domains that form the pore, determine selectivity, and interact with pore-blockers.