Key result
In pregnant women with diabetes, a 1% difference in HbA1c corresponded to a 0.67 mmol/l difference in average glucose, indicating that standard estimated average glucose values should be replaced by pregnancy-specific calculations.
Why the study?
Does a pregnancy-specific estimated average glucose (PeAG) calculation more accurately reflect average glucose levels from HbA1c in pregnant women with diabetes compared to standard eAG?
Observational (n=117)
Yes
Does a pregnancy-specific estimated average glucose (PeAG) calculation more accurately reflect average glucose levels from HbA1c in pregnant women with diabetes compared to standard eAG?
Effect estimate: coefficient 0.67 (95% CI 0.57-0.78)
The relationship between HbA1c and average glucose is altered by pregnancy, meaning standard eAG values should not be used; instead, a pregnancy-specific eAG (PeAG) is recommended.
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Challenges standard eAG use in pregnant women with diabetes; hypothesis-generating for pregnancy-specific formulas pending validation.
Law et al. (2017) conducted an observational in Pregestational type 1 or type 2 diabetes in pregnancy (n=117). HbA1c levels was evaluated on Association between HbA1c and average glucose values in pregnancy (coefficient 0.67, 95% CI 0.57-0.78). In pregnant women with diabetes, a 1% difference in HbA1c corresponded to a 0.67 mmol/l difference in average glucose, indicating that standard estimated average glucose values should be replaced by pregnancy-specific calculations.
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