Key result
Two 6-month-old male twins presenting with fever, diarrhea, and a diaper rash were diagnosed with eczema coxsackium, an atypical manifestation of hand, foot, and mouth disease, confirmed by PCR.
Why the study?
Eczema coxsackium is a rare, atypical manifestation of hand, foot, and mouth disease that can be easily mistaken for eczema herpeticum or impetigo.
Case Report (n=2)
Eczema coxsackium is a rare manifestation of hand, foot, and mouth disease that can present as an erythematous rash with eroded papules over the diaper region in infants.
Answers are grounded in this paper and cite their sources.
Alerts clinicians to eczema coxsackium in refractory diaper rashes; hypothesis-generating case report leaves broader validation open.
Eczema coxsackium is an atypical manifestation of hand, foot, and mouth disease (HFMD). It is a rare manifestation and can be easily mistaken for eczema herpeticum or impetigo. We report two male infants (twins) of 6 months of age who presented with 2 days of fever and diarrhea followed by an erythematous rash over the diaper region with multiple eroded papules. As the presentation coincided with a seasonal clustering of HFMD cases, eczema coxsackium was suspected. Polymerase chain reaction for pan-enteroviral RNA was positive in a throat swab, and a diagnosis of eczema coxsackium over the diaper dermatitis was made.
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Indra et al. (2023) conducted a case report in Eczema coxsackium (n=2). Two 6-month-old male twins presenting with fever, diarrhea, and a diaper rash were diagnosed with eczema coxsackium, an atypical manifestation of hand, foot, and mouth disease, confirmed by PCR.
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