Key result
Transcatheter mitral valve interventions, such as the MitraClip system, offer a safe and effective alternative to surgery for high-risk patients with severe mitral regurgitation.
Transcatheter mitral valve interventions, particularly the MitraClip, offer a promising alternative to surgery for high-risk patients with mitral regurgitation, with numerous other technologies currently in development.
Cautious consideration possible in select high-risk cases; leaves open need for RCTs to confirm durability and guide practice.
Mitral valve regurgitation (MR) is often diagnosed in patients with heart failure and is associated with worsening of symptoms and reduced survival. While surgery remains the gold standard treatment in low-risk patients with degenerative MR, in high-risk patients and in those with functional MR, transcatheter procedures are emerging as an alternative therapeutic option. MitraClip(®) is the device with which the largest clinical experience has been gained to date, as it offers sustained clinical benefit in selected patients. Further to MitraClip implantation, several additional approaches are developing, to better match with the extreme variability of mitral valve disease. Not only repair is evolving, initial steps towards percutaneous mitral valve implantation have already been undertaken, and initial clinical experience has just started.
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Maisano et al. (2013) conducted a review in Mitral valve regurgitation. Mitral Transcatheter Technologies was evaluated. Transcatheter mitral valve interventions, such as the MitraClip system, offer a safe and effective alternative to surgery for high-risk patients with severe mitral regurgitation.
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