Key result
About 36% of axon profiles in the rat basilar artery showed immunolabelling for endothelin-1, suggesting a neuronal role in the physiological control of the vessel wall.
The presence of endothelin in perivascular nerves suggests a neuronal role in the physiological control of the vessel wall.
Animal data only; leaves open neuronal endothelin-1 contribution to human cerebrovascular regulation.
The endothelium is recognized as a major source of endothelin in the vasculature. In this report we show for the first time that endothelin can be demonstrated with immunoelectronmicroscopy in perivascular nerves. About 36% of the axon profiles (varicosity/intervaricosity) examined in the rat basilar artery showed immunolabelling with a polyclonal antibody to endothelin-1. Endothelin-labelled axon varicosities were characterized by the presence of small spherical agranular vesicles (42 +/- 1 nm); some varicosities also contained large granular vesicles (92 +/- 5 nm) with labelled cores. Immunolabelling was mostly distributed in the axoplasm and in association with the membrane of synaptic vesicles (the lumen of the small agranular vesicles was immuno-negative). The presence of endothelin in perivascular nerves of the basilar artery suggests a neuronal as well as endothelial role in the physiological control of the vessel wall.
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Loesch et al. (1998) studied this question. Endothelin-1 immunolabelling was evaluated on Presence of endothelin in perivascular nerves. About 36% of axon profiles in the rat basilar artery showed immunolabelling for endothelin-1, suggesting a neuronal role in the physiological control of the vessel wall.
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