Key result
Intracisternal injection of endothelin-1 induced long-lasting, dose-dependent basilar artery contraction in cats and dogs, whereas vertebral artery injection had no appreciable effect.
Why the study?
Does endothelin-1 induce vasoconstriction in cerebral arteries from the adventitial or luminal side?
Population
Feline and canine basilar arteries (in vivo models)
Comparison
Endothelin-1 applied intracisternally or via… vs Comparison between intracisternal and vertebral…
Design
Preclinical
Follow-up
up to 12 hours
Authors
Loading...
May implicate adventitial endothelin-1 in cerebral vasospasm; hypothesis-generating and leaves open human translation.
Does endothelin-1 induce vasoconstriction in cerebral arteries from the adventitial or luminal side?
Endothelin-1 causes profound and long-lasting cerebral vasoconstriction only from the adventitial side, suggesting a potential role in the pathogenesis of cerebral vasospasm.
Shigeno et al. (1989) studied this question. Endothelin-1 (ET-1) vs. Vertebral artery perfusion vs cisternal injection was evaluated on Basilar artery caliber (vasoconstriction). Intracisternal injection of endothelin-1 induced long-lasting, dose-dependent basilar artery contraction in cats and dogs, whereas vertebral artery injection had no appreciable effect.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: