Why the study?
Do putative ECE inhibitors reduce big ET-1-induced isometric contraction in isolated rat basilar arteries?
Population
Isolated rat basilar artery segments (with intact endothelium or de-endothelialized)
Comparison
Putative endothelin-converting enzyme inhibitors… vs Big ET-1 alone (implied control)
Design
Preclinical
Authors
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Questions ECE inhibitor utility in cerebral vasospasm models; leaves open alternative big ET-1 processing pathways in cerebroarterial tissue.
Do putative ECE inhibitors reduce big ET-1-induced isometric contraction in isolated rat basilar arteries?
Standard ECE inhibitors do not effectively block big ET-1-induced contraction in rat basilar arteries, indicating a need to further elucidate cerebroarterial ECE activity to develop treatments for cerebral vasospasm.
Vatter et al. (1998) studied this question.
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