Key result
In patients with very small hearts (end-systolic volume ≤10 ml), peak filling rate calculated by HRV-F from G-SPECT significantly correlated with echocardiographic e' (r=0.47, p=0.006), whereas QGS showed no significant correlation.
Why the study?
Does ECG-gated myocardial perfusion SPECT accurately assess left ventricular diastolic function compared to ultrasound echocardiography in patients with small hearts?
Cross-Sectional (n=144)
Does ECG-gated myocardial perfusion SPECT accurately assess left ventricular diastolic function compared to ultrasound echocardiography in patients with small hearts?
In patients with small hearts, HRV-F software for ECG-gated SPECT provides better correlation with echocardiographic diastolic function than QGS, though accurate assessment remains challenging.
HRV-F may aid diastolic assessment by gated SPECT in small hearts versus QGS; hypothesis-generating and requires validation.
BACKGROUND: Assessment of left ventricular (LV) diastolic function is important because it is possible to detect early sign of myocardial ischemia by this assessment. The purpose of this study was to compare between electrocardiogram (ECG) -gated myocardial perfusion single photon emission computed tomography (G-SPECT) and ultrasound echocardiography in assessment of LV diastolic function in the small heart (SH). METHODS: The study population consisted of 144 patients who underwent both G-SPECT and ultrasound echocardiography. Peak filling rate (PFR), one-third mean filling rate (1/3 MFR) and the ratio of time to PFR to the RR interval (TPFR/RR) were calculated by quantitative gated SPECT (QGS) and heart risk view-F (HRV-F). Peak early mitral annular velocity (e') was used as the reference standard of LV diastolic function. RESULTS: There were 33 patients with end-systolic volume (ESV) of ≤10 ml (SH10), 51 patients with ESV of 11-20 ml (SH 20) and 60 patients with ESV of >20 ml (normal-sized heart: NH). In SH10, PFR calculated by QGS was not correlated with e'. However, that by HRV-F was significantly correlated with e' (r=0.47, p=0.006). On the other hand, 1/3 MFR and TPFR/RR calculated by QGS and HRV-F were not correlated with e' in SH10 and SH20. PFR, 1/3 MFR and TPFR/RR calculated by QGS and HRV-F were correlated with e' in NH.
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Chono et al. (2018) conducted a cross-sectional in Small heart (evaluation of left ventricular diastolic function) (n=144). ECG-gated myocardial perfusion SPECT (HRV-F and QGS) vs. Ultrasound echocardiography (e') was evaluated on Correlation between peak filling rate (PFR) calculated by HRV-F and peak early mitral annular velocity (e') in patients with end-systolic volume ≤10 ml (SH10) (r=0.47, p=0.006). In patients with very small hearts (end-systolic volume ≤10 ml), peak filling rate calculated by HRV-F from G-SPECT significantly correlated with echocardiographic e' (r=0.47, p=0.006), whereas QGS showed no significant correlation.
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