Key result
Phantomless quantitative computed tomography revealed that North Indian males experience continuous linear bone loss of 1.2 mg/cc per year after age 25, whereas females exhibit accelerated bone loss during the perimenopausal period.
Cross-Sectional (n=691)
This study provides reference bone mineral density values for a North Indian population using phantomless quantitative computed tomography, highlighting different patterns of age-related bone loss between males and females.
Offers North Indian-specific phantomless QCT norms; hypothesis-generating for sex-specific osteoporosis screening.
OBJECTIVE: The objective of the study is to generate reference values of bone mineral density (BMD) in north Indian population using phantomless quantitative computed tomography (QCT).MATERIALS AND METHODS: Bone mineral densities were generated from the computed tomography (CT) scans of 691 patients (390 males and 301 females, ages 11–85 years) who underwent CT of the abdomen or thorax for indications unrelated to bone diseases. The individuals were divided according to age groups from 11–15 to 80–85 years. BMD was calculated by phantomless QCT software by assessing L1 and L2 vertebrae.RESULTS: For females, the maximum BMD was observed for the age group of 21–25 years (144.67 mg/cc). The overall bone loss per year from 26 to 85 years was 1.62 mg/cc. Greater bone loss was seen from ages of 36–55 years which was 2.18 mg/cc. With bone loss per year being 0.99 mg/cc in ages from 26 to 35 years and 1.41 mg/cc from 56 to 85 years. Regression analysis gave a better fit using third order polynomial of age than did a linear regression line. For males, the maximum BMD was observed for the age group of 21–25 years (147.67 mg/cc). The overall bone loss per year from 26 to 85 years was 1.2 mg/cc. Regression analysis gave the best fit using linear regression.CONCLUSION: In the study population, the males show a linear relationship between age and BMD with continuous bone loss after the age of 25 years while females demonstrate a more complex relationship between age and BMD with accelerated bone loss in perimenopausal age group.
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Bhoil et al. (2018) conducted a cross-sectional in Bone mineral density reference values (n=691). Age was evaluated on Bone mineral density (BMD) and annual bone loss. Phantomless quantitative computed tomography revealed that North Indian males experience continuous linear bone loss of 1.2 mg/cc per year after age 25, whereas females exhibit accelerated bone loss during the perimenopausal period.
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