Key result
Visceral fat area was the strongest risk factor for cardiometabolic diseases, significantly increasing the odds of metabolic syndrome (OR 1.361 per 10 cm2 increase) compared to epicardial and subcutaneous fat.
Why the study?
Does epicardial and visceral fat accumulation associate with cardiometabolic diseases and coronary atherosclerosis in patients suspected of having angina pectoris?
Cross-Sectional (n=374)
No
Does epicardial and visceral fat accumulation associate with cardiometabolic diseases and coronary atherosclerosis in patients suspected of having angina pectoris?
Visceral fat is the strongest risk factor for cardiometabolic diseases, while epicardial fat accumulation may pose a risk for coronary atherosclerosis even in subjects without visceral fat accumulation.
Answers are grounded in this paper and cite their sources.
May aid cardiometabolic risk stratification via visceral fat in angina suspects; leaves open independent epicardial fat effects on atherosclerosis.
BACKGROUND: Excess of visceral fat is a central factor in the pathogenesis of metabolic syndrome (MetS) and atherosclerosis. However, little is known about how much epicardial fat affects cardiometabolic disorders in comparison with visceral or subcutaneous fat. METHODS AND Among the low VFA groups, the numbers of subjects with diabetes and coronary atherosclerosis were increased in high EFV group. Among the low EFV groups, the numbers of subjects with diabetes, hyperuricemia, and coronary atherosclerosis were increased among the high VFA subjects. In an age-, sex-, and body mass index (BMI)-adjusted model, EFV was associated with dyslipidemia and MetS, and VFA was significantly associated with hypertension, dyslipidemia, MetS, and coronary atherosclerosis, while SFA was not related with coronary risks and atherosclerosis. CONCLUSIONS: Epicardial fat accumulation may be a risk for coronary atherosclerosis in subjects without visceral fat accumulation. Visceral fat is the strongest risk for cardiometabolic diseases among the 3 types of fat depot.
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Sato et al. (2017) conducted a cross-sectional in Cardiometabolic diseases and suspected angina pectoris (n=374). Visceral fat area (VFA) and Epicardial fat volume (EFV) vs. Lower fat volume/area was evaluated on Metabolic syndrome (MetS) (OR 1.361, 95% CI 1.261-1.477, p=<0.0001). Visceral fat area was the strongest risk factor for cardiometabolic diseases, significantly increasing the odds of metabolic syndrome (OR 1.361 per 10 cm2 increase) compared to epicardial and subcutaneous fat.
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