Key result
The pooled prevalence of bicuspid aortic valve in patients with Turner syndrome evaluated by cardiac MRI or CT was 23.7%.
Why the study?
Reported bicuspid aortic valve prevalence in Turner syndrome ranges between 14% and 34%, leaving the specific prevalence unknown.
Meta-Analysis (n=1,177)
Effect estimate: 23.7% (95% CI 21.3% to 26.1%)
Bicuspid aortic valve is present in approximately 23.7% of Turner syndrome patients when assessed by cardiac MRI or CT, confirming it as the most common congenital heart defect in this population.
Turner syndrome (TS) is a rare disorder affecting 25–50 in 100000 female newborns. Bicuspid aortic valve (BAV) is assumed to be the most common congenital heart defect (CHD) in TS. In literature, reported BAV prevalence in TS ranges between 14% and 34%. The specific BAV prevalence in TS is still unknown. The aim of this study was to give a more precise estimation of BAV prevalence in TS by conducting a meta-analysis of TS-studies, which detected BAV by either cardiac magnetic resonance imaging (MRI) or cardiac computed tomography (CT). We searched PubMed, Cochrane Library, and Web of Science databases to collect observational studies including the prevalence of BAV identified by cardiac MRI or cardiac CT in TS patients up to June 4th, 2021. After screening for inclusion, data extraction, and quality assessment by two independent reviewers, the meta-analysis was performed with R 4.1.1 software. Results are shown as proportion and weighted mean difference with 95% confi- dence intervals (95% CI). In total, 11 studies involving 1177 patients were included. Pooled data showed that the prevalence of BAV in TS patients was 23.7% (95% CI: 21.3% to 26.1%). No high heterogeneity was found between the included studies. The current meta-analysis reveals that BAV can be detected in 23.7% of TS patients receiving cardiac MRI or cardiac CT. Therefore, BAV can be considered as the most common CHD in TS. Compared to TTE, cardiac MRI and cardiac CT might represent superior imaging modalities in BAV assessment of adult TS patients.
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Li et al. (2022) conducted a meta-analysis in Turner syndrome (n=1,177). Cardiac MRI or CT was evaluated on Prevalence of bicuspid aortic valve (23.7%, 95% CI 21.3% to 26.1%). The pooled prevalence of bicuspid aortic valve in patients with Turner syndrome evaluated by cardiac MRI or CT was 23.7%.
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