Key result
Hypertriglyceridemic waist phenotype linked to ~139% higher odds of subclinical atherosclerosis.
Why the study?
The authors sought to explore whether the hypertriglyceridemic waist phenotype could serve as an effective, cheap, and non-invasive test for subclinical atherosclerosis.
Does the hypertriglyceridemic waist (HTGW) phenotype predict subclinical atherosclerosis?
Meta-Analysis (n=2,136)
Does the hypertriglyceridemic waist (HTGW) phenotype predict subclinical atherosclerosis?
The hypertriglyceridemic waist phenotype is a simple and inexpensive screening tool that is significantly associated with a 2.4-fold increased odds of subclinical atherosclerosis.
Answers are grounded in this paper and cite their sources.
HTGW phenotype was associated with subclinical atherosclerosis; supports inexpensive screening but prospective validation needed before practice change.
Background: Atherosclerosis is a chronic, progressive inflammatory disease with a long asymptomatic period. Disease progression can eventually lead to acute cardiovascular events, such as myocardial infarction, unstable angina, and sudden cardiac death. Hypertriglyceridemic waist (HTGW) has received much attention recently as a cheap and non-invasive test. The purpose of our study was to explore whether the HTGW phenotype could be used as an effective test for subclinical atherosclerosis. Methods: We screened seven databases (PubMed, Cochrane Library, EMBASE, CNKI, WANFANG, CBM, and Web of Science) using both free terms and MeSH terms. Six published studies which evaluate the connection between HTGW and subclinical atherosclerosis were selected. Total carotid intima-media thickness (IMT) and carotid plaque are surrogate markers of subclinical atherosclerosis and predictors of cardiovascular events. Demographic and clinical data, data on HTGW and markers associated with subclinical atherosclerosis, along with odds ratios (OR), relative risks (RR), and hazard ratios (HR) with 95% confidence intervals were extracted. Data were then integrated using Stata 16. Results: A total of six studies conformed to inclusion criteria and revealed that HTGW is associated with subclinical atherosclerosis (OR = 2.39, 95% CI = 1.63-3.51). Conclusion: Available evidence supports the notion that HTGW can be an effective and inexpensive means of testing for atherosclerosis.
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Xiong et al. (2026) conducted a meta-analysis in Subclinical atherosclerosis (n=2,136). Hypertriglyceridemic waist (HTGW) phenotype vs. Individuals without the hypertriglyceridemic waist phenotype was evaluated on Subclinical atherosclerosis (OR 2.39, 95% CI 1.63-3.51). The hypertriglyceridemic waist phenotype was significantly associated with increased odds of subclinical atherosclerosis (OR 2.39).
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